- Shameik Moore (2 films)
- Shawn Ashmore (2 films)
- Shawnee Smith (2 films)
- Shelley Winters (2 films)
- Sheri Moon Zombie (2 films)
- Shirley MacLaine (2 films)
- Simon Abkarian (2 films)
- Simon McBurney (2 films)
- Simon Rex (2 films)
- Sissy Spacek (2 films)
- Sônia Braga (2 films)
- Sophie Okonedo (2 films)
- Spencer Breslin (2 films)
- Spiros Focás (2 films)
- Stephanie Hsu (2 films)
- Stephen Graham (2 films)
- Stephen McHattie (2 films)
- Sterling K. Brown (2 films)
- Steve Guttenberg (2 films)
- Steven Brand (2 films)
- Sylvie Testud (2 films)
- Sally Hawkins (3 films)
- Sandrine Kiberlain (3 films)
- Sara Paxton (3 films)
- Sarah Silverman (3 films)
- Sean Bean (3 films)
- Sidse Babett Knudsen (3 films)
- Simu Liu (3 films)
- Stellan Skarsgård (3 films)
- Stéphane De Groodt (3 films)
- Stephen Rea (3 films)
- Steve Zahn (3 films)
- Susan Sarandon (3 films)
- Swann Arlaud (3 films)
- Sacha Baron Cohen (4 films)
- Sandra Hüller (4 films)
- Saoirse Ronan (4 films)
- Sarah Paulson (4 films)
- Sarah Polley (4 films)
- Sean Penn (4 films)
- Sebastian Stan (4 films)
- Seth MacFarlane (4 films)
- Song Kang-ho (4 films)
- Stephen Lang (4 films)
- Suzanne Clément (4 films)
- Seann William Scott (5 films)
- Selena Gomez (5 films)
- Sam Neill (6 films)
- Sofia Boutella (6 films)
- Salma Hayek (7 films)
