- Simon Abkarian (2 films)
- Simon Callow (1 film)
- Simon Chandler (1 film)
- Simon Faliu (1 film)
- Simon Fenton (1 film)
- Simon Helberg (1 film)
- Simon MacCorkindale (1 film)
- Simon McBurney (2 films)
- Simon Pegg (12 films)
- Simon Rex (2 films)
- Simon Reynolds (1 film)
- Simone Griffeth (1 film)
- Simone Kirby (1 film)
- Simone Signoret (1 film)
- Simone Susinna (1 film)
- Simu Liu (3 films)
- Siobhan Reilly (1 film)
- Siran Riak (1 film)
- Sissy Spacek (2 films)
- Sistine Rose Stallone (1 film)
- Sixtine Murat (1 film)
- Sky Ferreira (1 film)
- Skyler Samuels (1 film)
- Slim Pickens (1 film)
- Slimane Dazi (1 film)
- Slimane-Baptiste Berhoun (1 film)
- Smita Tambe (1 film)
- Sobhan Javadi (1 film)
- Sofia Bent (1 film)
- Sofia Black-D'Elia (1 film)
- Sofia Boutella (6 films)
- Sofia Kappel (1 film)
- Sofia Lebedeva (1 film)
- Sofia Lesaffre (1 film)
- Sofía Vergara (1 film)
- Song Kang-ho (4 films)
- Sonia Acevedo (1 film)
- Sônia Braga (2 films)
- Sonia Maria Chirila (1 film)
- Sonoya Mizuno (1 film)
- Sophia Ali (1 film)
- Sophia Lillis (1 film)
- Sophia Myles (1 film)
- Sophia Reid-Gantzert (1 film)
- Sophie Marceau (1 film)
- Sophie Nélisse (1 film)
- Sophie Okonedo (2 films)
- Sophie Traub (1 film)
- Sophie Turner (1 film)
- Sophie Verbeeck (1 film)
